Effects of folic acid,vitamin B6 and vitamin B12 on ischemic penumbra in cerebral ischemia rats

Objective To investigate the effects of folic acid,vitam in B₆ and vitam in B₁₂ on ischem is penumbra in focal cerebral ischemia rats.Methods Sprague-Dawley rats were randomly divided into three groups of MCAO model group (MCAO),MCAO+folic acid group (MCAO+FA)and MCAO+compound vitamins (folic acid+vitam in B₆+vitam in B₁₂)group (MCAO+CV).Middle cerebral artery occlusionmodelwas induced by operation Then all rats received magnetic resonance in aging (MRI) brain scan.Results Apparent diffusion coefficients (ADC) in MCAO+FA (0.61±0.04) and MCAO+CV (0.63±0.04) group were significantly higher than that of in MCAO group (0.50±0.05,P<0.05).Aavemge diffusion coefficients (DCavg) in MCAO+FA (0.74±0.04) and MCAO+CV group (0.77±0.06) were also higher than that of in MCAO group (0.67±0.04) (P<0.05).Fractional anisotropy (FA)in MCAO+CV group (0.80±0.06) was significantly higher than that of in MCAO group (0.62±0.04,P<0.05).Conclusion Supplement of folic acid can inhibit the extend of ischem is core Simultaneous adm inistration of vitam in B₆ and vitam in B₁₂ shows an additive effect.