Study on t,t-2,4-DDE induced DNA oxidative damage in mice

Objective To study the effects of t,t-2,4-DDE on the oxidative DNA damage of mice.Methods The 8-oxod G,the biomarker of oxidative DNA damage in the mice seruminduced by the intraperitoneal injection of t,t-2,4-DDE was detected by HPLC-UV.Results The results showed that at a single dose of 1,10,50 mg/kg,8-oxodG in serum of the mice increased with the increase of drug dose,and exhibited dose-response relation ship(P<0.05).At the end of 2,6,10 days after exposed to,t,t-2,4-DDE at the dose of 50mg/kg,8-oxodG in serum of the mice increased with prolonged time,and had an obvious time-dependent fashion(P<0.01).Conclusion Exposure to t, t-2,4-DDE was supposed to induce the DNA oxidative damage in mice.