Association of hsp60 gene polymorphisms with coronary heart disease risk

Objective　To investigate the relationship between hsp60 polymorphisms and coronary heart disease (CHD).Methods With Taq Manallelic discrimination method and case-controls tudy,the f requenc ies of rs788016 and rs2340690 in 674 patients with CHD and 744 controls were determined.Results The frequencies of rs788016 and rs2340690 geno types were not different between cases and controls.After adjusting for sex,age and smoking status,the frequencies of rs788016 AA+AG geno type and re2340690 TT geno type in controls were sigificantly higher than that of in patients of male smoker and younger than 60 years.Compared with rs788016 GG geno type,subjects with AA+AG geno type had higher risk of CHD(OR=1.178,95%CI=1.04-3.03).The subjects with rs2340690 CC+CT genotype had similar risk compared with TT geno type(OR=0.58,95%CI=0.62-5.20).The male smoking subjects with rs788016 AA and AG geno type had almost twice of the risk of CHD(OR=1.74,95%CI=1.08-2.82)。Conclusion　The genotype of rs788016 may serve as a novel genetic marker for the risk of CHD.