Related factors of hyperuricemia among Han and Uygur people

Objective To study related factors of hyperuricemia among Han and Uygur people.Methods Totally 399 patients with hyperuricemia and 429 patients withouthyperuricemia and gout as controls were recruited in a hospital.The height,body weight,waist circumference(WC),hip circumference(HC),waist-to-height ratio(WHR),body mass index(BMI),and blood pressure of the patients were measured.The serum uric acid(SUA),triglyceride(TG),total cholesteral(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),very low-density lipoprotein cholesterol(VLDL-C) were determined and serum interleukin 6(IL-6),trmor necrosis factor α (TNF-α),C-reactive protein(CRP) were detected with ELISA.Results The TG,VLDL-C,body weight,BMI,WHR,WHTR,IL-6,CRP were increased and HDL-C decreased in hyperuricemia patients compared to that of control group.IL-6,TNF-α of Uygur hyper-uricemia patients were lower than that of Han hyperuricemia.There were positive correlations between SUA and body weight,WC,BMI,WHR,WHTR,TG,VLDL-C,IL-6,and CRP.Conclusion There may be the same basis for the incidence of hyperuricemia,obesity and metabolic disorder.The symptoms of chronic inflammation have relationship with hyperuricemia and influence the development of hyperuricemia.Levels of cytokine and features of abnormal metabolism in different race are different.