Association of lipoprotein lipase gene Hind Ⅲ,S447X polymorphism with metabolic syndrome and its components in Kazakh of Xinjiang

Objective To investigate the association between lipoprotein lipase gene Hind Ⅲ,S447X polymorphism and metabolic syndrome and its components.Methods PCR-RFLP was used to detect genotypes of lipoprotein lipase Hind Ⅲ and S447X among 401 subjects(201 controls and 200 metabolic syndrome patients).Results The genotype frequencies of H+H-/H-H-,H-allele,SX/XX,and X allele for metabolic syndrome were significantly lower than those of controls(H+H-/H-H-:33.5% vs 46.8%,P=0.012;H-allele:22% vs 28.6%,P=0.031;SX/XX:10.5% vs 22.9%,P=0.001;X allel:5.5% vs 12.44%,P=0.001).The waist circumference(WC),systolic blood pressure(SBP),diastolic blood pressure(DBP),trighyceride(TG),and fasting plasma glucose(FPG) in subjects with H+H-/H-H-genotype were significantly lower than those of with H+H+ genotype,and the high-density lipoprotein-cholesterol(HDL-C) among the subjects with H+H-/H-H-was significantly higher than that of with H+H+ genotype(P0.05 for all).The WC,SBP,DBP,TG and FPG in the subjects with SX/XX genotype were significantly lower than those of with SS genotype,and HDL-C was significantly higher than that of with SS genotype(P0.05 for all).The frequencies of H+H+ and SS genotype were increased along with the growing number of metabolic syndrome component.Conclusion The lipoprotein lipase gene Hind Ⅲ and S447X polymorphism are associated with metabolic syndrome risk in Kazakh,and H+H-/H-H-genotype,H-allele,SX/XX genotype and X allele may serve as protective factors for metabolic syndrome.H+H-/H-H-and SX/XX genotype has beneficial effect for all metabolic syndrome components,and the frequencies of H+H+ and SS genotype increase along with the number of metabolic syndrome component.