Effects of garlic oil on n-hexane induced peripheral nerve injury in rats

Objective To investigate the effects of garlic oil(GO) on n-hexane induced peripheral nerve injuries in rats.Methods Male SD rats were divided into four groups randomly(n=15 for each group):the control,the model,the low dose GO,and the high dose GO group.The low and high dose GO groups were admin istered intraga strically with GO (40 or 80 mg/kg·bw)and n-hexane(2500 mg/kg·bw) one hour after the GO treamtent.The model group was admin istered with equiva lent n-hexane.The treamtents were performed five tmies per week for eight weeks.Neuro behavioral tests were performed every two weeks,including hind lmib support,grip strength for fore limb,switching tail test and pressure pain test, and gait score wasm easured at the end of eight week.sResults Compared with the control group(7.28 cm),the hind lmib-support index of the model group(9.58 cm) increased significantly(P < 0.05).But in the low(7.94 cm) and high (6199 cm) dose GO groups,there was no significant change(P > 0.05).The grip-strength-for-fore lmib indices of four groups were 10.0,3.0,6.0,and 8.0s;the indices of two GO groups were lower than that of the control group(P < 0.05)but higher than that of the model group(P < 0.05).Gaitscores of two GO groups were better than that of the model group sig nificantly at the end of eight weeks(P < 0.05).Conclusion GO has protective effects on n-hexane induced peripheral nerve injuries in rats.