Protective effect of tomato juice on liver and kidney damage in mice with cadmium poisoning

ObjectiveTo study the effects of of tomato juice on promoting cadmium(Cd)excretion and liver and kidney damage induced by Cd in mice.MethodsThe mice were given Cd and different concentration of tomato juice.After 4 weeks,the Cd levels of liver and kidney,the activity of alanine amino tranferase(ALT)and the content of blood urea-nitrogen(BUN)in serum of the mice were measured.And the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),the content of malondia ldehyde(M DA)in serum,liver and kidney of the mice were also measured.ResultsCompared with the model group(15.6±0.11,11.2±0.45 g/g),the Cd levels of liver and kidney were significantly decreased in the low tomato juice group(12.4±0.52,9.3±0.37 g/g;P<0.01).The srum leve ls of ALT and BUN (204.4±15.2,11.1±2.05 mmol/L)were significantly decreased than those of model group(502.5±21.3,14.5±3.15 mmol/L;P<0.01).The contents of MDA in serum,liver and kidney in the low tomato juice group(10.5±1.2, 10.7±2.1,11.3±1.2 nmol/mg·prot)were decreased.However,the activities of SOD and GSHPx increased.The protective effects showed dose effect trend.ConclusionTomato juice has protective effect on the damage of liver and kidney induced by Cd in mice,which is related to the increase of antioxidative effect.