Association between IL-10-819 polymorphism and susceptibility to hepatitis B virus infection in Han, Yi and Yao minority of Guizhou

Objective To investigate the association between in terluekin 10(IL-10)-819 gene polymorphism and susceptibility to hepatitis Bvirus(HBV) infection in Han, Yi and Yao mino rity in Guizhou provnce.Methods We selected 500 volunteers from Guizhou provice.A llelic frequencies of IL-10-819 were measured with PCR SSP.Results There was a significant difference in IL-10-819 genotype frequencies between the minority and the whole population(P < 0.05).The distributions of geno type frequency of IL 10-819 were statistically different among Yao ethnic and Han ethnic in Libo, Yi ethnic in Q ianxi and Yi ethnic in We ining, and Han ethnic in Libo(P < 0.05).IL-10-819 polym orphism was associated with HBV infection in Yi ethnic in Qianxi and Hanethnic in Libo.Conclusion IL-10-819 g enepolymorphisms influence susceptibility to HBV infection in Han, Yao, Yi population in Guizhou.The study suggests that IL-10-819 genepolymorphisms maybe a risk factor for HBV in fection.