Oxidative stress of salt-sensitive hypertension induced by sensory denervation

Objective To explore oxidative stress of salt-sensitive hypertension induced by sensory denervation.Methods Male Wistar rats were given 50 mg/kg capsaic in subcutaneously on the 1st and 2nd day of life.The control rats were treated with vehicle.After weanling period,the rats in treated and control groups were subdivided into 2 groups,respectively,and fed different saltdiets for 4 weeks(control,high sodium diet,capsaicin,and capsaicin plus high sodium diet).The model of salt sensitive hyper tension induced by sensory denervation was established.The plasm a content of malondialdehyde (MDA) and nitrogen monoxide(NO),the plasm a activity of super oxide dismutase(SOD) and nitric oxide synthase(NOS) were tested.Results The tail-cuff systolic blood pressure (mmHg) of capsaic in plus high sodium group increased significantly (151.43±4.20).The content of MDA were significantly higher in capsaicin plus high sodium group(2.14±0.51 nmol/L) than that of the control group,capsaicin group and high sodium group(P < 0.05 for all).The plasm a activity of SOD (185.04±3.62 U/m l) and NOS(16.99±2.98 U/ml),and the plasm a content of NO (49.12±3.86 mol/L) were all significanatly lower in capsaicin plus high sodium group than that of the control group and high sodium group (P < 0.01).The indexes also decreased in capsaic in plus high sodium group than in high sodium group(P < 0.05).Conclusion There is oxidative stress in the rats with salt-sensitive hypertension induced by sensory denervation.