Impacts of 12 T ultra strong static magnetic fields on gene expression of catalase and glutathione peroxidase in mice

Objective To study the effect of ultra strong static magnetic field(USMF) on gene expressions of catalase (CAT) and glutathione peroxidase(GSHPx) in mice.Methods One-week-aged mice were exposed to USMF at 12 Tesla (T) for 8,12 or 16 hours.Total liver RNAs was then extracted.Expression levels of CAT mRNA and GSH-Px-mRNA were mea sured with quantitative RTP-CR6 12 or 24 hours after the exposure.Results CAT-mRNA and GSH-Px-mRNA levels in 12hr-treated mice incresed to 1.154 and 0.881(optical absorption ratio) without significant increase compared to those of the controls.CAT-mRNA and GSH-Px-mRNA levels in 16hr-treated mice was upregulated (1.112 and 0.887,optical absorption ratio) 6 hours after the exposure.Conclusion Gene expressions of CAT and GSH-Px,the markers of antioxidant ability,are not impaired by 12TUSMF treatment in mice.