Effect of Fructus corni polysaccharides on testis tissue damage induced by warm bath in rats

Objective To study the effect of Fructus corni polysaccharides (FCP) on rats' testis tissue damage induced by warm bath.Methods Different doses of FCP (0,10,50,100,150 mg/kg/d) were given in tragastrically to SD rats.Fourteen days after the treamtent,the model was constructed by warmbath.The morphological change of testis,organ index of testis and epididymis,sperm count and motility,superoxide dismutase (SOD) activity,malond idehyde (MDA) content,and the apoptosis of germ cell were observed.Results FCP could miprove the damage of the testis,and the role was more obvious with the increase of the dose.Compared with the activity of SOD (195.05±25.62 NU/mg±prot) and the content of MDA (3.02±1.18 nmol/mg±prot) in the damaged group,the activity of SOD (285.34±24.37 NU/mg±prot) increased and the content of MDA (1.48±0.63 nmol/mg±prot) decreased in 150 mg FCP group.Compared with the damaged group(64.05±1.35%),the apoptosis of sperm cell(15.50±1.06%) decreased significantly for ratswith FCP of 150 mg,and the results were significanty different(P < 0.01,P < 0.05).Conclusion FCP has protective effect on testis tissue damage induced by warm bath in rats.