Influence of abnormal glucose tolerance during pregnancy on pregnanty outcome

ObjectiveTo investigate the impact of gestational diabetes mellitus(GDM)and gestational impaired glucose tolerance(GIGT)on pregnant women and newborns.MethodsTotally 250 pregnant women hospitalized for their deliveries and diagnosed with GDM(105)or GIGT(145)were recruited in the study.And 234 pregnant women with normal blood glucose level were taken as control group at the same time.The pregnancy outcomes of the three groups were recorded and analyzed.ResultsThere were signifiicant differences among the three groups in the incidences of hepatitis B virus(HBV)positive(P=0.009),caesarean birth(P=0.000),gestational hypertension(P=0.002), intrahepatic cholestasis of pregnancy(P=0.004),preterm delivery(P=0.027),small-for-date infant(P=0.011),neonatal hypoglycemia(P=0.007),neonatal pneumonia(P=0.001),and neonate hospitalization(P=0.000)among the three groups.Compared with those of the control group,there were significantly increased risks for HBV positive (P=0.041),caesarean birth(P=0.000),gestational hypertension(P=0.001),intrahepatic cholestasis of pregnancy (P=0.009),preterm delivery(P=0.012),small-for-date infant(P=0.019),neonatal hypoglycemia(P=0.03),neonatal pneumonia(P=0.000),and neonatal intensive care unit(NICU)admission(P=0.000)in the GDM group.The pregnant women in GIGT group showed higher risks of HBV positive(P=0.041),caesarean birth(P=0.000),gestational hypertension(P=0.021),intrahepatic cholestasis of pregnancy(P=0.021),preterm delivery(P=0.048),neonatal hypoglycemia(P=0.021),neonatal pneumonia(P=0.004),and NICU admission(P=0.000).ConclusionGDM and GIGT could cause undesirable pregnancy outcomes.The perinatal screening for gestational abnormal glucose metabolism and standardized treatment for GDM and GIGT should be strengthened to improve pregnanty outcomes among the wonen.