Association of Pro12Ala and C1431T polymorphisms of PPAR2 gene with metabolic syndrome in Xinjiang Kazakh

Objective To investigate the association of peroxisome proliferator activated receptor(PPAR)γ2 gene Pro12Ala and C1431T polymorphisms with metabolic syndrome.Methods Matrix assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS) was used to detect PPARγ2 gene Pro12Ala and C1431T genotypes in 489 subjects(245 metabolic syndrome patients and 244 controls).Results The frequencies of Pro12Ala genotype(χ²=0.050,P=0.822) and allele(χ²=0.108,P=0.742) showed no significant differences between the patients and the controls.The frequencies of C1431T CC genotype and C allele for metabolic syndrome patients were all higher than those of the controls(CC genotype:78.8%vs 68.4%,P=0.01; C allele:87.6%vs 83.0%,P=0.044).Multiple logistic regression analyses suggested that risk factor for metabolic syndrome was CC genotype(OR=2.043).The results of interaction analyses for different factors indicated that the risk for metabolic syndrome in alcohol drinkers with CC genotype was 2.788 times of that non-drinkers with CT/TT genotype.Conclusion The PPARγ2 gene C1431T polymorphism is associated with metabolic syndrome risk in Kazakh.CC genotype and C allele may serve as genetic risk factors of metabolic syndrome and CC genotype and alcohol drinking may have additive effect on metabolic syndrome.