Effect of angiotensin converting enzyme inhibitor combined with comprehensive intervention on treatment outcome and living quality in old patients with chronic heart failure

Objective To analyze the effect of angiotensin converting enzyme inhibitor combined with comprehensive intervention treatment on treatment outcome and living quality in elder patients with chronic heart failure.Methods A total of 328 elder patients with chronic heart failure were randomly divided into intervention group and control group.Control group accepted routine treatment of angiotensin converting enzyme inhibitor and the intervention group accepted angiotensin converting enzyme inhibitor combined with comprehensive intervention for six months.The change of cardiac function,living quality and adverse cardiovascular events in the two groups were observed.Results Totally 285 elder patients with chronic heart failure completed the study eventually(156 in intervention group and 129 in control group).No difference in cardiac function between the two groups was observed before intervention(P>0.05).According to the classification of New York Heart Association,in the intervention group there were 15 cases with heat function at I level,82 cases at Ⅱ level,42 cases at Ⅲ level,17 cases at Ⅳ level,and left ventricular ejection fanction (LVEF),N-terminal pro-B-type natriuretic peptide(N-proBNP),and six-minutes walk test(6MWT)were 46.4±7.9%,1 510±530 ng/mL,and 430.8±84.5 m after six months' intervention,with significant differences compared with those before the intervention(P<0.05 for all);while for the control group,5 case at I level,54 cases at Ⅱ level,43 cases at Ⅲ level,27 cases at Ⅳ level,and the value of LVEF,NT-proBNP,and 6 MWT were 41.2±7.0%,1830±590 ng/mL,and 348.4±71.2 m,with statistical difference compared with that before treatment only for NT-proBNP(P<0.05).Physical condition sensory and language exchange function,drainage function,intelligence,and emotions of the patients were all improved in the intervention group compared with those before the intervention(P<0.05 for all);while for the control group,only physical condition was improved after the intervention (P<0.05).The second incidence rate of cardiovascular adverse events in the intervention group(26.8%)was lower than that in the control group(52.4%,P<0.05).Conclusion The treatment of angiotensin converting enzyme inhibitor combined with comprehensive intervention can significantly improve cardiac function and living quality of the elderly patients with chronic heart failure.