Evaluation on multi-drug resistant tuberculosis control strategies in 5 pilot cities in Zhejiang province

ObjectiveTo evaluate the multi-drug resistant tuberculosis (MDR-TB)control strategies implemented in 5 pilot cities in Zhejiang province,and to provide evidence for further MDR-TB control.MethodsTotally 7 140 smear positive TB patients from 5 cities (Hangzhou,Huzhou,Shaoxing,Quzhou,and Lishui)were screened and tested.The MDR-TB cases diagnosed were treated and followed with standard procedure.Statistical description and univariate analysis were used to analyze MDR-TB case-finding and treatment data collected.ResultsDuring the study period,537 MDR-TB cases were detected and 351 patients were treated with standard anti-MDR therapy.Totally 71.4%of the MDR-TB patients turned to culture-negative after finishing the first 6 months course.The cure rate of MDR-TB patients who finished the 2-year treatment were 71.0%.The detection ratio of drug sensitive test (DST)among the treated and retreated failure cases was 52.4%and 67.4%,respectively.The detection ratio of new smear positive cases was 2.5%.The major reasons for the MDR-TB patients who were not enrolled and treated with standard anti-MDR therapy were successful former treatment regime (26.2%),migration or default (20.6%),treatment deficiency (19.8%)and deaths before enrolment (15.1%).ConclusionThe MDR-TB control strategies applied in Zhejiang province were proved to be practical and efficient.However,the problems such as low enrolment rate,high treatment suspending proportion,side effect,and long-term treatment outcome need to be studied.