Risk factors of hyperuricemia in Uygur and Han population:a case-control study

Objective To investigate risk factors of hyperuricemia among Uygur minority and Han nationality in Xinjiang Uygur Autonomous Region(Xinjiang),and to provide scientific basis for making intervention measures.Methods With questionnaire survey,physical examination and laboratory test,a hospital-based case-control study was conducted among 825 inpatients of hyperuricemia aged between 20 to 70 years from the First Affiliated Hospital of Xinjiang Medical University during February to December 2012 and 1001 age-matched physical examinees in the same hospital and during the same period.Results The ratios of smoking,alcohol drinking,lack of exercise,obesity,dyslipidemia,and hypercholesterolemia in the Uygur minority cases were 51.4%,53.2%,80.0%,48.20%,69.82%,and 24.32% and all of which were higher than those of the controls(24.2%,33.2%,37.7%,36.27%,49.73%,and 18.67%;P<0.05 for all).The ratios of smoking,alcohol drinking,regular intake of meat,lack of exercise,obesity,dyslipidemia,hypercholesterolemia,hypertension,and hyperglycemia in Han nationality cases were 55.9%,59.6%,84.0%,76.6%,25.46%,76.64%,38.06%,21.26%,and 17.85%and also were all higher than those of the comtrol(38.5%,47.1%,76.4%,55.4%,7.88%,44.59%,23.42%,9.23%,and 24.77%;P<0.05 for all).Multivariate conditional logistic regression analyses showed that the risk factors of hyperuricemia for Uygur minority were smoking(odds ratioOR=2.71,95%confcdence interval95%CI:1.98-3.715),alcohol drinking(OR=1.58,95%CI:1.164-2.148),obesity(OR=1.60,95%CI:1.186-2.148),dyslipiemia(OR=1.743,95%CI:1.289-2.357),with regular exercise as a protective factor(OR=0.157,95%CI:0.115-0.213).The risk factors of hyperuricemia for Han nationality were smoking(OR=1.637,95%CI:1.181-2.270),hypertension(OR=1.757,95%CI:1.117-2.766),obesity(OR=3.003,95%CI:1.917-4.706),dyslipidemia(OR=2.900,95%CI:2.082-4.040),and hypercholesterolemia(OR=1.773,95%CI:1.261-2.491),with regular exercise as a protective factor(OR=0.415,95%CI:0.298-0.575).Conclusion There are differences between different ethnic groups in the risk factors of hyperuricmia,including smoking,lack of exercise,hypertension,obesity,dyslipidemia,and hypercholesterolemia.