Risk factors of nonsyndromic cleft lip with or without cleft palate among Uygur and Han populations in Xinjiang

Objective To investigate risk factors of nonsyndromic cleft lip with or without cleft palate(NSCL/P) among Uygur and Han populations in Xinjiang Uygur Autonomous Region(Xinjiang)for making effective preventive measures.Methods A case-control study was carried out among 185 Uygur and Han cases and 105 age-,sex-,and ethnic-matched controls selected from 6 hospitals in Xinjiang;the data collected by a face-to-face interview were analyzed with univariate and multivariate logistic regression analysis.Results There were significant differences in gender,maternal health condition,and maternal history of getting cold during the pregnancy between Uygur NSCL/P cases and controls(all P< 0.05);significant differences between Han NSCL/P cases and controls were also observed in education level and alcohol drinking history of the father,maternal working intensity during the early pregnancy(all P< 0.05).Conclusion Ethnic differences exist in NSCL/P risk factors between Uygur and Han populations.Male gender,maternal illness conditions,maternal history of getting cold during pregnancy are risk factors of NSCL/P in Uygur population;education level and alcohol drinking history of the father,heavy working history during early pregnancy of the mother are risk factors of NSCL/P in Han population.