Association between serotonin receptor genes and suicide behavior

ObjectiveTo explore the associations of single nucleotide polymorphism(SNP) of 5-hydroxytryptamine-1B receptor(5-HT1BR) gene rs6298,5-hydroxytryptamine 2A receptor(5-HT2AR) gene rs6311 and rs6313,and 5-hydroxytryptamine 2B receptor(5HT2BR) gene rs765458 with suicidal behavior.MethodsThe blood samples of 281 depression patients with impulsive suicide attempt and 300 age-matched healthy physical examinees were selected in a hospital from November 2012 through March 2014.The DNA of the blood samples was extracted and genoptyped with TapMan SNP genotyping probe.χ² test was adopted in statistical analyses to compare the differences in the distribution of gene alleles between the cases and controls.ResultsThere were significant differences in the genotype frequencies of 5-HT2AR gene rs6311(χ²=20.736,P=0.000) and rs6313(χ²=7.645,P=0.022) between the cases and the controls.No significant differences were observed in genotypes of 5-HT1BR gene rs62985 and 5-HT2BR gene rs765458 and in the allele frequencies of 5-HT1BR gene rs6298,5-HT2AR gene rs6311 and rs6313,and 5-HT2BR gene rs765458 between the cases and the controls(all P>0.05).ConclusionThe SNPs of 5-HT2AR gene rs6311 and rs6313 are significantly associated with suicidal behavior,but the SNPs of 5-HT1BR gene rs6298,5-HT2BR gene rs765458 have no significant association with suicidal behavior.