Pathogenicity of severe fever with thrombocytopenia syndrome bunyavirus in China:an overview

Studies have ascertained that "tick bite event" occurring in more than ten provinces and leading to dozens of deaths in China in recent years was a human infectious disease caused by severe fever with thrombocytopenia syndrome bunyavirus(SFTSV).SFTSV particles are spherical with surface spines, and mainly distribute in the microsomes of the infected cells.The genome of the virus is consisted of three(large, medium and small) single strand RNA negative chains, coding RNA polymerase, virus membrane protein and non-structure protein, respectively.The clinical manifestations of SFTSV infection are fever, nausea, vomiting, rapid decrease of peripheral blood platelet in most of the infected cases, and damage of liver, kidney and other organ.This review focused on the research progress in China and abroad on the etiology, relevant diseases, immune response, and detection of SFTSV to provide reference for early diagnosis and prevention of Bunia virus.