Plasma EPA and DHA levels and their relationship with ApoB100/ApoA1 ratio in patients with acute coronary syndrome

Objective To examine associations of plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels with apolipoprotein B100 (ApoB100)/apolipoprotein A1 (ApoA1) ratio among patients with acute coronary syndrome (ACS),and to provide references for ACS prevention and control.Methods A cluster sample of 860 examinees having coronary angiography were selected at The Second Affiliated Hospital of Mudanjiang Medical College and Mudanjiang Hongqi Hospital between June 2011 and June 2016 and 610 of them diagnosed as ACS were assigned into a case group and 250 with negative checkup result into a control group,respectively.Levels of plasma EPA and DHA,serum ApoB100 and ApoA1,and the ratio of serum ApoB100/ApoA1 of the participants were determined and compared between the cases and the controls.The relationships between plasma EPA and DHA and serum ApoB100/ApoA1 ratio were analyzed.Results Significantly lower plasma EPA (3.02±0.25% vs.3.51±0.32%),DHA (2.42±0.24% vs.2.88±0.29%) and serum ApoA1 (1.21±0.25 g/L vs.1.42±0.32 g/L) and higher serum ApoB100 (1.05±0.23 g/L vs.0.73±0.12 g/L) and ApoB100/ApoA1 ratio (0.87±0.22 vs.0.51±0.160.51±0.16) were observed in the cases than in the controls (all P<0.001).Spearman correlation analyses revealed significantly reverse correlations between ApoB100/ApoA1 ratio and plasma EPA (r=-0.762) and DHA (r=-0.783)among the ACS cases (both P<0.001).Conclusion Plasma EPA and DHA and serum ApoB100/ApoA1 ratio may be indicators for the diagnosis and prognosis of patients with acute coronary syndrome.