Genetic association between polymorphism of claudin 5 transmembrane protein gene and schizophrenia

  Objective   To investigate the association between schizophrenia and the polymorphism of claudin 5 transmembrane protein deleted in velocardiofacial syndrome(CLDN5).

  Methods   PCR-Restrictive Fragment Length Polymorghism was used to examine the G/C single nucleotide polymorphism(SNP)of CLDN5 with 173 muclear family trios of schizophrenia.

  Results   The result of TDT indicated that the allelic frequency transmitted from the heterozygote parents didn't deviate 50%;There was significant relationship between CLDN5 genotype and delusion of influence(P < 0.05).

  Conclusion   As far as Chinese han schizophrenia in this paper are concerned, the association between the polymorphism of CLDN5 and schizophrenia may not be assured, but the effect of polymorphism of CLDN5 on psychotic symptoms in schizophrenia cann't be exculded.