Study on relation between leptin, NPY mRNA and obesity-resistant

  Objective   To study the level of leptin and NPY mRNA of DIO and DIO-R rats and the relation between NPY, leptin and obesity-resistant.

  Methods   The level of leptin were determined by radioimmunnoassay.The NPY mRNA were detected in situ hybridization.

  Results   At week 2, the NPY mRNA expression of DIO-R rats were lower than those of DIO rats(P < 0.05), the level of leptin of DIO-R rats was higher than that of DIO rats and the control(P < 0.05);At week 12, the level of leptin of DIO-R rats were decreased as compared with DIO rats and increased as compared with the control(P < 0.05).

  Conclusion   Decreased NPY mRNA and the kept leptin sensitivity might be related to obesity-resistant.