Effect of purified water on hepatic expression of LDL-R in rats

  Objective   To investigate the effect of purified water on hepatic expression of low density lipo profein receptor (LDLR)in rats.

  Methods   60 male and female Wistar rats were equally randomized into 3 groups 〔tap water group(TW), pur ified water group(PW)and purified water+MgSO₄ group(PW+Mg)〕, Levels of hepatic LDLR mRNA were examined by RTPCR after 6 months treatment.

  Results   Compared with the TW(control group), a decrease trend in LDLR of gene expression in PW and an increase trend in LDLR of gene expression in PW+Mg which compared with the PW were observed, but no differences were seen among all groups.

  Conclusion   Compared with the TW(control group), drinking PW group and PW+Mg group did not obviously affect the levels of hepat ic LDLR mRNA in rats.