Effect of nickel sulfate on ion concentration and content of mitochondrion in liver cells of rats

  Objective   To study the toxic effect of nickel sulfate on the liver cells in rats.

  Methods   Nickel sulfate was injected intraperitoneally for Wistar rats daily at different doses(1.25, 2.50, 5.00 mg/kg)for 21 days.On the 22^nd day, to measure ion concentration of Ca²⁺, Mg²⁺, Ni²⁺, Na⁺ and H⁺ and the content of mitochondrion in the liver cells with alser confocal scanning microscopy.

  Results   In the liver cells, the levels of Mg²⁺and the content of mitochondrion were lower than those in the control rats, but the ion concentraton of Ca²⁺, Ni²⁺, Na⁺and H⁺ increased.

  Conclusion   The disorder of the ion concentration and the content of mitochondrion in the liver cells were caused by nickel sulfate and its hurt in the liver cells.