Evaluation of efficacy dose on inactivated HAV vaccine

  Objective   To evaluate the immune dose of Aluminium adjuvant absorbed inactivated HAV vaccines.

  Methods   Firstly, after desorption of 4 lotsof inactivated HAV vaccines made from 4 pharmaceutical factories respectively, HAV antigen content was detected by ELISA; Then potency test was performed in mice in vivo, and the mean efficacy dilution was calculated to evaluate the immunogenicity of different vaccines.

  Results   The content of HAV antigen desorpted from the final products deviated apparently from the immunogenicity efficacy, the mean effective dose(ED₅₀)can't be used as the parameter for evaluation these vaccines'immunogenicity.

  Conclusion   The mean efficacy dilution can be used as the parameter to evaluate the immune dose on inactivated HAV vaccines.