Detection of hepatitis B virus Pre-S1 antigen in serum and its relationship with HBV DNA and HBeAg

  Objective   To investigate the relativ ity between hepatit is BV irus Pre-S1A ntigen(PreS1Ag)and HBV DNA, HBeAg.And fur ther to judge the value of PreS1Ag detection.

  Methods   In 225 HBsAg positive serum, preS1Ag and HBV marks were detected by enzyme linked immunosorbent assay(ELISA)and HBV DNA was tested by poly merase chain reaction-ELISA(PCR-ELISA).

  Results   The positive rate of PreS1Ag in the two groups of HBV DNA positive and HBeAg positive was obviously higher than that of the negative group; the positive rate of PreS1Ag in the group of HBeAg negative was 43.0%.The coincidence rate of PreS1Ag with HBV DNA and HBeAg were 70.6%, 68.4% respectively.

  Conclusion   There are a good relationship among PreS1Ag and HBV DNA, HBeAg.PreS1Ag is more sensitive than HBeAg in judging the infectiion and replication of HBV.