Effect of lycopene on antioxidative enzyme in acute liver damage rats

  Objective   To obser ve the protective effect of lycopene(LP)on acute injury induced by Carbon T etrachloride (CCl₄)in rats.

  Methods   Rats were given lycopene by oral.After 4 weeks the activ ity of super oxide disutase(SOD), malondi aldehyde(MDA)and glutathione peroxidase(GSH-Px), reduced glutathione(GSH), total-antioxidation capacity(T-AOC)in serum and liver were measured respectively.

  Results   The activities of antio xidative activity in model group were reducd.Compared with model group, the activities of SOD, GSH, TAOC and GSH-Px in LP group were increased and the concentrations of MDA were descreased significantly(P < 0.05).

  Conclusion   LP can incr ease antioxidative activity, and decrease the damage of liver in rats.