Case-control study on environmental risk factors of lung cancer in Nanjing population

  Objective   To study the environmental!risk factors of lung cancer in Nanjing population.

  Methods   A 1:1 match case-control study was carried out,which involved 63 cases of primary pulmonary squamous cell carcinoma and 89 cases of pulmonary adenocarcinoma.The environmental risk factors were analyzed by conditional logistic regression model.

  Results   Chronic bronchitis and quantity of smoking were found to be risk factors to lung squamous cell carcinoma.The OR value was 8.55,2.35,respectively,and population attributable risks(PAR)for each of them was 18.22%,58.80%,respectively,the total PAR was 68.71%.The risk factors related to lung adenocarcinoma were chronic bronchitis,the history of pulmonary tuberculosis,bad cooking habituation,use of coal stove and family histoty of cancer.The respective OR value was 5.16,4.12,2.91,2.02,2.59,and PAR was 8.15%,11.91%,27.30%,29.98%,10.35%,respectively.Summary PAR for the five factors above was 63.06%.

  Conclusion   The development of pulmonary squamous cell carcinoma and adenocarcinoma was related with various environmental factors respectively.Strengthening the control of the environmental risk factors was suggested to reduce the incidence of lung cancer.