Effects of soybean isoflavone on bone biomechanics in ovariectomized rats

  Objective   To explore the benefit effects of soybean isoflavone on BMD and bone biomechanics property in ovariectomized rats.

  Methods   The rats were sham-operationed and divided into 6 groups.There were Ovx group(ovariectomized control group)soybean isoflavone group, estrogen group and Sham group.After feeding sixteen weeks, the rats were killed and femur were separated.BMD and flexural strengh and flexural elastic module were measured.Bone wet weights and dry weights and ash weights were weighed.

  Results   The BMD of Ovx group decreased significantly and femur biomechanics markers changed obviously.Soybean isoflavone and estrogen can increase BMD(P < 0.01)and express dose-dependent manner.Flexural strengh and flexural elastic module increase.Femur length and different state weights in estrogen group were significant lower than other groups and there were no obvious changes in other groups.

  Conclusion   Soybean isoflavone and estrogen can increase femur BMD and had benefit effects on bone biomechanics property.