Effect of DNA preparation on antioxidant action in old rat's tissues

  Objective   To investigate the effect of exogenous DNA on the production of lipid peroxide(LPO)and the activities of superoxide dismutase(SOD)in aging rat's cardiac muscle, liver and kidney.

  Methods   Twenty healthy spragueDawley(SD)male rats were chosen and randomly divided by abdominal cavity with 0, 3.0 mg of DNA preparation in every day for 22 days.All rats of each group were killed at the 23th days and their cardiac muscel, liver, kidney were collected and used in determining contents of LPO and activites of SOD.

  Results   The contents of LPO was significantly lower in DNA group than in the control group.The activites of SOD were increased in DNA group.

  Conclusion   DNA may have the effect on cleaning oxygen free radical and antioxidant action wich can delay the aging of cardiac muscle, liver and kidney.