Study on cell cycle of testis cells mouse treated by B(a)P

  Objective   Effects of B(a)P on the cell cycle of testicle cells of male mice were studied.

  Methods   The flow cytometry was used to study the effects of B(a)P on testicle cells of male mice.

  Results   The different doses of B(a)P could make the testicle cell cycle change.The cells in G₀/G₁, S phase decreased with the increase of B(a)P.There were significant differences among the 5, 10, 20 mg/kg and negative control(P < 0.05).The accounts of cells in G₂/M increased and there were significant differences between experimental groups and negative control(P < 0.05).

  Conclusion   B(a)P can inhibit DNA synthesis of testicle cells, cause the G₂ block and delay the mitosis of testicle cells.