Effect of GPC on blood lipids level and lipid peroxidation in high fat dietary rats

  Objective   To study the comprehensive effect of different dietary factors such as high fat diet(HFD), alcohol, Grape procyanidins(GPC), VE on blood lipids and lipid peroxidation in rats.

  Methods   Adult Wistar rats were divided into normol group(N), HFD group(F), HFD+alcohol group(FA), HFD+GPC group(FG), HFD+alcohol+GPC(low and high dose, FAGL and FAGH), HFD+alcohol+VE group(FAE), seeded for 6 weeks.Serum TG, TC, HDL-C, LDL-C, ROS, MDA level, SOD activity were examined.

  Results   Serum TG, TC, ROS, MDA levels of F, FA group were significantly increased than before experiment, serum TC, MDA level of FAGH group were significantly lower than FA group, SOD activity was significantly higher.

  Conclusion   Alcohol can aggraviate the increase of blood lipids levels and lipid peroxidation induced by HFD, GPC can inhibite the increase of blood lipids level and increase antioxidation.