Effects of tomato paste on antioxidant in rats induced by nitrosamine

  Objective   To study effects of tomato paste on antiox idation in rats induced by N-methy l-N-amylni-trosamine(MANA).

  Methods   Wistar rats were randomly divided into three groups: simple MANA(M), MANA plus to matopaste(M+TP)and contro l(C)group.The experiment lasted for 26 weeks.The levels of ROS unit, SOD, GSH-Px and MDA in the blood were determined and histolo gical examination was done.

  Results   The levels of antiox idant in the blood of rats were decreased and content of oxidation were increased as the experiment lasted.Compared with M group, activity of ROS unit, SOD.GSH-Px in M+TP group were significantly higher and content of MDA in M+TP was significantly lower than those in M group(P < 0.01)after 22 weeks.Precancerous lesions and carcinoma of esophagus or forestomach were observed in M and M+TP groups.The incidence of typical hyperplasia in week 22 and carcinoma in week 26 in M+TP group were lower than those in M group.

  Conclusion   The levels of antioxidant and oxidant in the blood of rats were dynamic raised first and decreased later.The inhibitory effect may be due to tomato paste which may improve antioxidation in rats.