Effects of folic acid on growth of human gastric cancer cell line in vitro

  Objective   To study the antitumor activities of folic acid.Folic acid are dealed with human gastric cancer cell line SGC-7901 in vitro.

  Methods   By means of four approaches as follows: cell proliferation cur veanalysis, MTT assay and cell cycle analysis by FCM.

  Results   After treatment with 375, 750 and 1 875 nmol/L, folic acid selectively inhibited the activity and function of SGC-7901.There are apoptotic peaks in cell cycle analysis by FCM and apoptosis rate reached 33.1%.

  Conclusion   The effects of folic acid on human embryo muscle sinew cells were slightly, which indicated that folic acid had no bad effects on normal cell, but inhibited tumor cell.