Effects of iron on endoplasmic reticulum and mitochondrial injury of myocardial cell

  Objective   To investigate effects of iron on the endoplasmic reticulum and mitochondria of the myocardial cells.

  Methods   To use model of cultured fetal mouse heart, in vitro, the fetal mouse hearts were cultured in culture liquid with 140μg FeSO₄/ml for 12 h.

  Results   Injury of endoplasmic reticulum was ahead of mitochondria.Structure of mitochondria around endoplasmic reticulum damaged lightly was complete and their cristae were clear.However, cristae of mitochondria around endoplasmic reticulum damaged severely were unclear.

  Conclusion   Unsynchronism injury of endoplasmic reticulum and mitochondria may be related to three-dimensional structure between two organellae and, to regulative disorder of Ca²⁺-A TPase between two organellae.