Pulmonary cacinoma pathological change caused by COF in Balb/C mouse

  Objective   To study the chronic toxicity of cooking oil fumes(COF), the pathological changes of lung tissues of Balb/C mice exposed to COF were observed.

  Methods   Balb/C mice were used to make chronic toxicity model.COF groups were exposed to COF of 3 kinds of different concentration(9.09±0.38), (20.65±0.93), (38.85±2.38)mg/m³ for 150 times in eight months for 30 min each time.At the same time the control group inhaled heated air(22-30℃)for 150 times in eight months.HE stainning was used to study the pathological changes.

  Results   The main pathological changes of COF groups were characteristic of inflammation with alveolar epithelial hyperplasia, adenic metaplasia, adenomatoid hyperplasia and atypical hyperplasia.There were 28 cases of pulmonary adenocarcinomata and 1 case of small cell carcinoma.In the control group, none case of carcinoma was observed, only minority experimental animal had inflammation and local mild epithelial hyperplasia.

  Conclusion   Precancerous lesion and canceration of lung tissues of Balb/C mice may be induced by COF; The carcinomata induced by COF were mainly pulmonary adenocarcinoma.COF may be suspicious carcinogen to human.