Epidemiologic study on iufluencing factors of congenital malformation

  Objective   To study the influencing factors and the interactions of the factors of congenital malformation; to put forward the key intervention factors.

  Methods   1:1 matched case-control study was carried out with 374 congenital malformation cases gathered by cluster sampling in Shandong.All of the data were analysed with simple and multiple conditional Logistic regression models.

  Results   Positive congenital malformation family history(OR=3.987), long period from pregnancy to be known(OR=2.483), fever during early pregnancy(OR=3.881), taking medicines during pregnancy (OR=3.038), exposure to injurants during early pregnancy(OR=2.968), maternal degree of education(OR=0.648), nutrition during early pregnancy(OR=0.325), negative life events stimulus during pregnancy(OR=1.252)were the influencing factors of congenital malformation.There were comprehensive interactions between positive congenital malformation family history and other infuencing factors.

  Conclusion   Congenital malfomation was caused by multiple influencing factors.There were positive or negative additive model interactions between positive congenital malformation family history and some environmental factors.