Effects of soybean isoflavone on liver lipids of ovariectony rats with high fat diet

  Objective   To study the effects of soybean isoflavone(SI)on lipid's metabolism and lipid peroxidation in the liver of ovariectony rats fed with high fat diet.

  Methods   50 SD rats were randomly divided into 5 groups: sham ovariectony and normal diet control; ovariectony and high fat diet control; ovariectony and high fat diet with three concentrations of SI supplied 120, 60, 180 mg/(kg·bw·d) groups.The duration of exposure was 8 weeks.

  Results   Compared with the OVX group, SI can significantly decrease the concentration of triglyceride in both serum and liver of the hyperlipidemic rats(P < 0.05), but there was no effect on the contents of total cholesterol in the liver(P > 0.05).Compared with the normal and OVX groups, SI can significantly decrease the concentration of MDA of the liver tissue as well(P < 0.01).

  Conclusion   SI can decrease the level of hypertrigly ceride in the liver of the ovariectony rats and it can also decrease the peroxidative damage of the liver by means of ameliorating the abnormal peroxidative state in liver.