Case-control study on hypertension and multiple metabolic disorders

  Objective   To explore the relationship between hypertension and multiple metabolic disorders.

  Methods   Based on the two community populations in south Jiangsu province from Chinese multicenter cardiovascular health cooperative project, a case-control study was conducted including 448 cases of essential hypertension and 1 120 controlled patients.

  Results   Various metabolic syndromes were higher in cases than in controls, regardless in both male and female subjects.Among cases, 79.69% of them had at least one more metabolic abnormalities as compared 58.44% in controls.The adjusted odds ratio (aOR)of cases who had 3 metabolic syndromes was 7.13, with 95%CI: 4.16-11.50.The a OR of cases with other abnormal metabolic syndrome ranged 2.0-5.0.However, there was no significant difference in complicated diabetes between the cases and the controls, a OR=1.36(95%CI: 0.56-3.27).The occurrence of multile metabolic syndromes in hypertensive patient was associated with certain behavior factors(smoking, alcohol, physical activities).Howerver, the proportions of post and current smoking and physical activities at leisure time were significantly higher in the cases than in the controls.In addition, family history of hypertension was associated with occurrence of multiple metabolic syndromes in patients with hypertension.

  Conclusion   Among hypertensive patients, 80% of them complicated with at least one metabolic syndrome, 30% with two and more metabolic abnormalities.Overweight/obese and diabetes were the commonest metabolic syndromes.In order to reduce metabolic disorders in hypertensive patients, multiple lifestyle behavior interventions such as losing weight were as important as blood pressure control.