Relationship between tumor necrosis factor alpha and insulin resistant of Wistar fat rats induced by diet

  Objective   To explore the relationship between obesity, IR and TNFA.

  Methods   To get Wistar fat rats by feeding them with high fat food, and ratio of fat to body weight is the criteria to divide groups.TNFA protein level of serum, muscle, liner and fat tissues were measured.IR of animal and human was assessed by IAI.

  Results   TNFA in fat tissue of fat rats group was significantly higher than that in normal group, and TNFA in serum, muscle, liver were not obviously different between the two groups.

  Conclusion   TNFA had an important role during the IR of obesity.TNFA results in IR of various tissues by different styles.