Study on association between HLA-DR phenotype and intrauterine transmission of hepatitis B virus

  Objective   To study the association between HLA-DR phenotype and intrauterine transmission of hepatitis B virus to probe into the genetic susceptibility to intrauterine infection of hepatitis B virus.

  Methods   Newborns born by HBsAg positive mothers in Taiyuan infectious hospital were selected and following study were conducted.By simple random sampling, 20 newborns with intrauterine infection of HBV or not were selected, respectively.HLA-DR genotyping was conducted with PCR-sequence specific primer(PCR-SSP).The frequency of HLA-DR phenotype and difference between two groups were analyzed.

  Results   The frequency of DR3、DR51 in intrauterine infection group(45%, 40%)was higher than in un-infected group(20%, 15%).OR was 3.27 (0.67-17.08), 3.78(0.69-23.02).The frequency of DR53 in un-infected group(60%)was higher than in infected group (35%).OR was 0.36(0.08-1.54).None of differences were significant.

  Conclusion   DR3 and DR51 were the susceptive phenotype and DR53 was the protective phenotype to intrauterine infection of HBV.But further study including more samples was necessary.