Study on blocking function of HBIG on intrauterine infection of HBV

  Objective   To study the effect of HBIG on HBV intrauterine infection during pregnancy of HBsAg female carrier.

  Methods   162 patients were treated with HBIG 200 IU every month from week 28.Intrauterine infection of HBV were studied by detecting HBsAg in newborns in 24 hours after birth.The results of group with HBIGwere compared with the previous results of 196 cases without HBIG as control.

  Results   The HBsAg positive rate of the newborns in HBIG group was 1.85% and that of control group was 5.61% (χ²=3.33, P=0.068).No adverse reaction were discovered on mothers and newborns.

  Conclusion   The intrauterine infection of HBV possibly could be decreased by using HBIG during pregnancy.