Study on unscheduled DNA synthesis of lymphocytes in mice treated with MeHg

  Objective   To understand effects of MeHg on DNA damage and repair in lymphocytes of blood and thymus of mice.

  Methods   Unscheduled DNA synthesis was used in vitro.

  Results   MeHg could make UDS increase in some range.There were significant differences between 1.00 mmol/L blood lymphocyte and 5.00mmol/L lymocyte compared with the control group(P < 0.05).The UDS of the low doses and the high doses gruops was decreased compared with that of the control group.

  Conclusion   MeHg could caused the lymphocytes DNA damage in the blood and thymus, and MeHg had genetic and immune toxicities.