Study on peripheral lymphocytes DNA damage and detection of serum SOD, LPO in smokers

  Objective   To investigate fumitoxin s(such as nicotine)damage to lymphocytes DAN and influence on human lipid perox idation level and to study their correlations.

  Methods   Peripheral lymphocytes of 61 smokers and 30 non-smokers were cultured, then sister chromatid exchange(SCE)rate was observed, the levels of serum superoxide dismutase(SOD)and lipid perox idation (LPO)were detected.

  Results   In smokers group, the levels of SCE and LPO were significantly increased and that of SOD was significantly decreased.The level of SCE was significantly positively correlated with that of LPO, and was signficantly negatively correlated with that of LPO.

  Conclusion   Fumitoxin(such as nicotine)decreased human antioxidant ability and caused DNA damage.