Study on DNA damage and simina deformity of mice induced by motorbike exhaust

  Objective   To research the DNA damage and semina deformity of motorbike exhaust using lead-free gasoline.

  Methods   40 mice were distributed in four groups randomly.The exposed groups were administrated by gavage with absorbent solution deluted by distilled water in 1:2, 1:4, 1:16, one time every day for 40 days.The DNA damage in the lymphocytes of blood and semina deformity rate in mice were detected.

  Results   The motorbike exhaust caused by using lead-free gasoline could cause DNA single strand breaks in the lymphocytes of blood.There were higher significantly compared with the control group(P < 0.01).It could increase the frequency of semina deformity.There were significant difference compared with the control group(P < 0.05).

  Conclusion   The motorbike exhaust using lead-free gasoline had the genotoxicity.