Analysis on polymorphism of CYPIIB2 gene of crowd with essential hypertension in China

  Objective   To investigate the distribution of the polymorphism of CYPIIB2 gene in essential hypertension (EH)pedigree in China.

  Methods   The blood pressure of the subjects with essential hypertension in two areas are investigated cross-sectionally since 2000, totally 600 fitable families with EH, and 800 subjects having the hypertension.

  Results   The 3 kinds of the CYPIIB2 genotypes are classified by the genetic variation, the homozygous mutation CC, the heterozymgous CT, and the mild TT.The frequency of allele C and T account for 28.2% and 71.81%.

  Conclusion   CYPIIB2 gene(344T)have point mutation in the essential hypertension in China, and three geno types(TT、T C、CC).