FBAT analysis on polymorphism of angiotensin Ⅱ receptor Ⅰ gene(A1166C)

  Objective   FBAT method was used to analyze the correlation between polymorphism of the angiotensin Ⅱreceptor Ⅰ gene(AT1R, A1166C)and the treatment effect of antihypertensive drug-Benazepril.

  Methods   Blood pressure for the subjects before and after taking Bnenazepril in essential hypertension patients in the west of A nhui were observed.Polymerase chain reaction(PCR)combined with restriction fragment length polymorphism(RFLP)were used to detect genetype frequency and polymorphism for AT1R for the patients and their pedigree.

  Results   The frequency of allele A and C accouted for 96% an 4% in the total populations.Through chi-square test, it met with H-W balance(χ²=0.31, P > 0.05).The result of family based associated test(FBAT)showed the C allele had notable correlation with the HDBP, SBPEFF and DBPEFF.

  Conclusion   This was the first time in China to detect the CC of AT1R(A1166C)gene polymorphism.The result of PBAT analysis showed that Callele of AT1R gene might be receptor sensitivity to the ACEI drugs.