Anti-respiratory syncytial virus effect of herba patrinea in vitro

  Objective   To explore anti-respiratory syncytical virus effect of herba patrinea.

  Methods   The herba patinea was extracted with hot water, condensed and sterilized.The toxicology of the aqueous extract was tested by adding the diluted extract directly to HeL a cells and its effect on RSV was estimated by the CPEI assay.

  Results   The TC₅₀ and EC₅₀ of the herba patrinea were 32mg/ml and 0.54 mg/ml, respectively.The TI was 59.26.Moreover, herba patrinea gave a dose-dependent response in inhibiting RSV.In the assay testing the effect of herba patrinea on viral growth, herba patrinea showed active effect on RSV when it was added at 0, 2, 4 h after infection.

  Conclusion   Herba patrinea may be a novel anti-RSV drug and it was worthy of further studying.