Study on HBV transmission from father to infant

  Objective   To study HBV transmission from father to infant, the study was carried out.

  Methods   The study contained 16 pairs of fathers who were HBV carriers, and infants whose mothers were not HBV carriers.The infants infected HBV in womb.The homogenous of HBS gene were compared between fathers and infants.

  Results   The serotype of 16 pairs fathers and infants were adw.The homogenous of HBVS gene were 98%-100%.The mutation of 488, 491, 494, 530, 531, 546, 581 621 nucleotide of S gene caused in 112, 113, 114, 126, 131, 143, 156 amino acid substitution.In the gene classification of HBVS gene, HBV of 10 pairs of fathers and infants were allocated group B.HBV of 4 pairs of fathers and infants were allocated to group A.Other 2 pairs, HBV of infants were allocated group A, while that of 2 fathers were allocated to group A and group B.

  Conclusion   The HBV transmission from father to infant was existed.The HBV gene classification of fathers and infants was consistent.