Association between epidemic hemorrhagic fever and HLA-DR alle polymorphish

  Objective   To explore the association between epidemic hemorrhagic fever(HFRS)and HL A-DRalle polymorphish.

  Methods   Twenty-eight normal people and 39 HFRS patients of Han nationality in Zunyi were tested for HLA-DR by poly merase chain reaction with sequence specific primers(PCR-SSP).

  Results   HLA-DRB3 ^* gene frequencies with HFRS was markedly higher in patients than in controls(RR=5.04, χ ²=9.988, P < 0.01);HLA-DRB1 ^*09012 gene frequencies significantly lower in patients(RR=0.24, χ ²=7.216, P < 0.01);while the frequencies of other DR alleles were not significantly increased in patients.

  Conclusion   HFRS be positive related to HLA-DRB3 ^* and was negatively related to HLA-DRB1 ^*09012.